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Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson’s Disease

Oxidative stress, neuroinflammation and apoptosis are some of the key etiological factors responsible for dopamin(DA)ergic degeneration during Parkinson’s disease (PD), yet the downstream molecular mechanisms underlying neurodegeneration are largely unknown. Recently, a genome-wide association study...

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Principais autores: Hariharan Saminathan, Anamitra Ghosh, Danhui Zhang, Chunjuan Song, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-04-01
Serier:Frontiers in Pharmacology
Fag:
Fyn
PKCδ
neurodegeneration
phosphorylation
kinase
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2021.631375/full
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