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Niclosamide improves cancer immunotherapy by modulating RNA-binding protein HuR-mediated PD-L1 signaling

Abstract Background Immune checkpoint blockade (ICB) represents a revolutionary advance in cancer treatment but remains limited success in triple-negative breast cancer (TNBC). Here we aim to explore the mechanism of RNA-binding protein (RBP) HuR in cancer immune evasion by post-transcriptionally re...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Qi Zhang, Zhe Yang, Xinbao Hao, Lauren J. Dandreo, Lily He, Yuxia Zhang, Fen Wang, Xiaoqing Wu, Liang Xu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2023-10-01
Schriftenreihe:Cell & Bioscience
Schlagworte:
RNA-binding protein
HuR
PD-L1
Immunotherapy
Niclosamide
Immune evasion
Online-Zugang:https://doi.org/10.1186/s13578-023-01137-w
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