Inhibition of HuR/ELAVL-1 attenuates fibrotic progression in Mdx mice with dilated cardiomyopathy

Abstract Duchenne muscular dystrophy (DMD) arises from dystrophin deficiency, a crucial component of the dystrophin-glycoprotein complex (DGC) essential for maintaining cellular structural integrity by linking intracellular actin filaments to the basal lamina. Dysfunctions within this complex, coupl...

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Hauptverfasser:	Andrea Farini, Monica Molinaro, Debora Mostosi, Mattia Camera, Michele Russo, Emma Leonetti, Mirella Meregalli, Lucia Prandi, Carla Liaci, Alessandra Ghigo, Emilio Hirsch, Giorgio Merlo, Yvan Torrente
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer 2025-12-01
Schriftenreihe:	Cellular and Molecular Life Sciences
Schlagworte:	Duchenne muscular dystrophy Dilated cardiomyopathy RNA binding proteins HuR
Online-Zugang:	https://doi.org/10.1007/s00018-025-05979-0
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