Systemic–airway eosinophil discordance and sputum mediator profiling in severe asthma treated with biologics: a retrospective cohort study

Abstract Background Biologic therapies have expanded treatment options for severe asthma; however, systemic biomarkers do not always reflect airway inflammation. Induced sputum may provide complementary information for inflammatory phenotyping and for exploring predictors of treatment response. Obje...

Полное описание

Библиографические подробности

Главные авторы:	Moe Tanaka, Toshiyuki Koya, Wakana Uji, Hiroki Koda, Masahiro Endo, Kyoichiro Oshima, Haruka Sofuku, Takahiro Matsuda, Shun Naramoto, Hiroshi Ueno, Ami Aoki, Kenjiro Shima, Yosuke Kimura, Toshiaki Kikuchi
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2026-04-01
Серии:	BMC Pulmonary Medicine
Предметы:	Asthma Induced sputum Sputum eosinophil IL-6 Biologics Clinical remission
Online-ссылка:	https://doi.org/10.1186/s12890-026-04275-2
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