Systemic–airway eosinophil discordance and sputum mediator profiling in severe asthma treated with biologics: a retrospective cohort study

Abstract Background Biologic therapies have expanded treatment options for severe asthma; however, systemic biomarkers do not always reflect airway inflammation. Induced sputum may provide complementary information for inflammatory phenotyping and for exploring predictors of treatment response. Obje...

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Hlavní autoři:	Moe Tanaka, Toshiyuki Koya, Wakana Uji, Hiroki Koda, Masahiro Endo, Kyoichiro Oshima, Haruka Sofuku, Takahiro Matsuda, Shun Naramoto, Hiroshi Ueno, Ami Aoki, Kenjiro Shima, Yosuke Kimura, Toshiaki Kikuchi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-04-01
Edice:	BMC Pulmonary Medicine
Témata:	Asthma Induced sputum Sputum eosinophil IL-6 Biologics Clinical remission
On-line přístup:	https://doi.org/10.1186/s12890-026-04275-2
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