Valproate regulates inositol synthesis by reducing expression of myo-inositol-3-phosphate synthase
Abstract Inositol depletion is a hypothesized mechanism of action of mood stabilization drugs used in the treatment of bipolar disorder. It was previously reported that the mood stabilizer valproate (VPA) increased phosphorylation of myo-inositol-3-phosphate synthases (MIPS), the rate limiting enzym...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Portfolio
2023-09-01
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| Collection: | Scientific Reports |
| Accès en ligne: | https://doi.org/10.1038/s41598-023-41936-2 |
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