Intravitreal AAV vector delivery induces integrin-dependent ocular inflammation, complement activation, and antiviral and DNA damage responses

BackgroundIntravitreal delivery of adeno-associated virus (AAV) vectors offers a promising, minimally invasive strategy for retinal gene therapy, but remains limited by dose-dependent intraocular inflammation. Corticosteroid therapy, the current standard for managing gene therapy-associated uveitis...

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Autors principals:	Helena Costa-Verdera, Deepa Jamwal, Emily Fabyanic, Ariel Hippen, Madeleine Salvatore, Aiping Du, Anna Majowicz, David Markusic, Jon E. Chatterton, Virginia Haurigot, Klaudia Kuranda
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-04-01
Col·lecció:	Frontiers in Immunology
Matèries:	AAV gene therapy antiviral immunity DNA damage response integrins intravitreal AAV injection ocular gene transfer
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1799327/full
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