Intravitreal AAV vector delivery induces integrin-dependent ocular inflammation, complement activation, and antiviral and DNA damage responses

BackgroundIntravitreal delivery of adeno-associated virus (AAV) vectors offers a promising, minimally invasive strategy for retinal gene therapy, but remains limited by dose-dependent intraocular inflammation. Corticosteroid therapy, the current standard for managing gene therapy-associated uveitis...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Helena Costa-Verdera, Deepa Jamwal, Emily Fabyanic, Ariel Hippen, Madeleine Salvatore, Aiping Du, Anna Majowicz, David Markusic, Jon E. Chatterton, Virginia Haurigot, Klaudia Kuranda
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-04-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	AAV gene therapy antiviral immunity DNA damage response integrins intravitreal AAV injection ocular gene transfer
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1799327/full
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!