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Targeting MYCN in Molecularly Defined Malignant Brain Tumors

Misregulation of MYC genes, causing MYC overexpression or protein stabilization, is frequently found in malignant brain tumors highlighting their important roles as oncogenes. Brain tumors in children are the most lethal of all pediatric malignancies and the most common malignant primary adult brain...

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Principais autores: Anna Borgenvik, Matko Čančer, Sonja Hutter, Fredrik J. Swartling
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-01-01
Serier:Frontiers in Oncology
Fag:
MYCN
brain tumor
targeted therapies
c-MYC
OCT4
medulloblastoma
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2020.626751/full
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