Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly
Abstract In neuronal exocytosis, SNARE assembly into a stable four-helix bundle drives membrane fusion. Previous studies have revealed that the SM protein Munc18-1 plays a critical role for precise SNARE assembly with the help of Munc13-1, but the underlying mechanism remains unclear. Here, we used...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2020-07-01
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| Series: | Scientific Reports |
| Acceso en liña: | https://doi.org/10.1038/s41598-020-68476-3 |
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