Dynamic conformational changes in munc18 prevent syntaxin binding.
The Sec1/munc18 protein family is essential for vesicle fusion in eukaryotic cells via binding to SNARE proteins. Protein kinase C modulates these interactions by phosphorylating munc18a thereby reducing its affinity to one of the central SNARE members, syntaxin-1a. The established hypothesis is tha...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science (PLoS)
2011-03-01
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| Col·lecció: | PLoS Computational Biology |
| Accés en línia: | http://europepmc.org/articles/PMC3048386?pdf=render |
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