Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state

Here, the enzymatic activity of APOBEC3G resulting in conversion of 2′-deoxy-zebularine into a hydration product allowed the authors to capture the transition state, which provides a blueprint for designing a new class of transition state-mimicking inhibitors for this class of enzyme.

Detalhes bibliográficos

Principais autores:	Atanu Maiti, Adam K. Hedger, Wazo Myint, Vanivilasini Balachandran, Jonathan K. Watts, Celia A. Schiffer, Hiroshi Matsuo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2022-11-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-022-34752-1
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