Binding pose depth modulates photoswitchable ligands’ efficacy at the 5-HT2A receptor
Abstract Photoswitchable ligands enable reversible control of receptor signaling through light-induced cis–trans isomerization, yet predicting how subtle structural modifications affect efficacy remains challenging. Here, we use molecular dynamics simulations to investigate two azobenzene-based huma...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2026-02-01
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| coleção: | Communications Chemistry |
| Acesso em linha: | https://doi.org/10.1038/s42004-026-01936-5 |
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