Application of a novel RNA-protein interaction assay to develop inhibitors blocking RNA-binding of the HuR protein

RNA-protein interactions play an important regulatory role in several biological processes. For example, the RNA-binding protein HuR (human antigen R) binds to its target mRNAs and regulates their translation, stability, and subcellular localization. HuR is involved in the pathogenic processes of va...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Larissa Filcenkova, Annika Reisbitzer, Benjamin Philipp Joseph, Verena Weber, Paolo Carloni, Giulia Rossetti, Sybille Krauß
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2025-03-01
Цуврал:	Frontiers in Genetics
Нөхцлүүд:	RNA-protein-binding split-luciferase assay NanoBiT AU-rich elements HuR inhibitor
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1549304/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!