PDK1-dependent metabolic reprogramming regulates stemness and tumorigenicity of osteosarcoma stem cells through ATF3

Abstract Osteosarcoma stem cells (OSCs) are characterized by their self-renewal and multilineage differentiation abilities, contributing to osteosarcoma malignancy. The Warburg effect describes cancer cells’ preference for glycolysis over mitochondrial oxidative phosphorylation (OXPHOS) for energy p...

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Autors principals:	Kazuya Tokumura, Kazuya Fukasawa, Jiro Ichikawa, Koki Sadamori, Manami Hiraiwa, Eiichi Hinoi
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2025-07-01
Col·lecció:	Cell Death and Disease
Accés en línia:	https://doi.org/10.1038/s41419-025-07903-7
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