PDK1-dependent metabolic reprogramming regulates stemness and tumorigenicity of osteosarcoma stem cells through ATF3
Abstract Osteosarcoma stem cells (OSCs) are characterized by their self-renewal and multilineage differentiation abilities, contributing to osteosarcoma malignancy. The Warburg effect describes cancer cells’ preference for glycolysis over mitochondrial oxidative phosphorylation (OXPHOS) for energy p...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2025-07-01
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| Series: | Cell Death and Disease |
| Acceso en liña: | https://doi.org/10.1038/s41419-025-07903-7 |
| Tags: |
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