Inhibition of 11β-hydroxysteroid dehydrogenase 1 alleviates pulmonary fibrosis through inhibition of endothelial-to-mesenchymal transition and M2 macrophage polarization by upregulating heme oxygenase-1

Abstract The intracellular enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) catalyzes the interconversion of active glucocorticoid (cortisol) and its intrinsically inert form (cortisone) in metabolic tissues. Although 11βHSD1 is considered a promising therapeutic target in metabolic disorder...

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Principais autores:	Su-Yeon Lee, Ji-Hee Kim, Yeonhwa Song, Sanghwa Kim, Hyo Jin Kang, Jason Kim, Yoon-Jin Lee, Haeng Ran Seo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2025-03-01
coleção:	Cell Death and Disease
Acesso em linha:	https://doi.org/10.1038/s41419-025-07522-2
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