Inhibition of 11β-hydroxysteroid dehydrogenase 1 alleviates pulmonary fibrosis through inhibition of endothelial-to-mesenchymal transition and M2 macrophage polarization by upregulating heme oxygenase-1
Abstract The intracellular enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) catalyzes the interconversion of active glucocorticoid (cortisol) and its intrinsically inert form (cortisone) in metabolic tissues. Although 11βHSD1 is considered a promising therapeutic target in metabolic disorder...
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| Principais autores: | , , , , , , , |
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| 格式: | Artigo |
| 语言: | Inglês |
| 出版: |
Nature Publishing Group
2025-03-01
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| 丛编: | Cell Death and Disease |
| 在线阅读: | https://doi.org/10.1038/s41419-025-07522-2 |
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