Conductance Changes of Na⁺ Channels during the Late Na⁺ Current Flowing under Action Potential Voltage Clamp Conditions in Canine, Rabbit, and Guinea Pig Ventricular Myocytes

Late sodium current (I_Na,late) is an important inward current contributing to the plateau phase of the action potential (AP) in the mammalian heart. Although I_Na,late is considered as a possible target for antiarrhythmic agents, several aspects of this current remained hidden....

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Autori principali:	Balázs Horváth, Zsigmond M. Kovács, Csaba Dienes, József Óvári, Norbert Szentandrássy, János Magyar, Tamás Bányász, András Varró, Péter P. Nánási
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2023-04-01
Serie:	Pharmaceuticals
Soggetti:	late Na<sup>+</sup> current ventricular repolarization action potential voltage clamp ventricular myocytes mammalian heart
Accesso online:	https://www.mdpi.com/1424-8247/16/4/560
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