USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin

Synapse formation and growth are tightly controlled processes. How synaptic growth is terminated after reaching proper size remains unclear. Here, we show that Leon, the Drosophila USP5 deubiquitinase, controls postsynaptic growth. In leon mutants, postsynaptic specializations of neuromuscular junct...

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Autori principali:	Chien-Hsiang Wang, Yi-Chun Huang, Pei-Yi Chen, Ying-Ju Cheng, Hsiu-Hua Kao, Haiwei Pi, Cheng-Ting Chien
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	eLife Sciences Publications Ltd 2017-05-01
Serie:	eLife
Soggetti:	USP5/Leon postsynaptic growth ubiquitin homeostasis Ubiquilin/Ubqn free ubiquitin chains
Accesso online:	https://elifesciences.org/articles/26886
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