Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis

Abstract Background Deubiquitinating enzymes (DUBs) are pivotal in maintaining cell homeostasis by regulating substrate protein ubiquitination in both healthy and cancer cells. Ubiquitin-specific protease 10 (USP10) belongs to the DUB family. In this study, we investigated the clinical and pathologi...

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Detalhes bibliográficos

Principais autores:	Zuxi Feng, Yanghuan Ou, Xueqiang Deng, Minghao Deng, Xiaohua Yan, Leifeng Chen, Fan Zhou, Liang Hao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-09-01
coleção:	Cell & Bioscience
Assuntos:	Osteosarcoma USP10 ULK1 GSK3β
Acesso em linha:	https://doi.org/10.1186/s13578-024-01291-9
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