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Structure Activity Relationship of N-Substituted Phenyldihydropyrazolones Against Trypanosoma cruzi Amastigotes

Current drugs for Chagas disease have long treatment regimens with occurrence of adverse drug effects leading to poor treatment compliance. Novel and efficacious medications are therefore highly needed. We previously reported on the discovery of NPD-0227 (2-isopropyl-5-(4-methoxy-3-(pyridin-3-yl)phe...

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Principais autores: Maarten Sijm, Louis Maes, Iwan J. P. de Esch, Guy Caljon, Geert Jan Sterk, Rob Leurs
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-04-01
coleção:Frontiers in Chemistry
Assuntos:
structure activity relationship
chagas disease
phenotypic optmization
trypanosama cruzi
phenylpyrazolones
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fchem.2021.608438/full
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