3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity

As there is a continuous need for novel anti-infectives, the present study aimed to fuse two modes of action into a novel 3-nitroimidazo[1,2-b]pyridazine scaffold to improve antiparasitic efficacy. For this purpose, we combined known structural elements of phosphodiesterase inhibitors, a target rece...

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Detalhes bibliográficos

Principais autores:	Yang Zheng, Joachim Müller, Stefan Kunz, Marco Siderius, Louis Maes, Guy Caljon, Norbert Müller, Andrew Hemphill, Geert Jan Sterk, Rob Leurs
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-08-01
Colecção:	International Journal for Parasitology: Drugs and Drug Resistance
Assuntos:	3-nitroimidazo[1,2-b]pyridazine Synthesis Giardia lamblia 3′,5′-cyclic nucleotide phosphodiesterase In vitro
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211320722000100
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