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Alpha-synuclein seeding amplification assays in Lewy body dementia: a brief review

Abstract Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), is characterized by cognitive decline, sleep disturbances, motor dysfunction, and other debilitating clinical symptoms. Neuropathologically, LBD is characterized by the progressi...

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Principais autores: Maria Bregendahl, Zeynep Bengisu Kaya, Wolfgang Singer, Pamela J. McLean
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-07-01
Serier:Molecular Neurodegeneration
Fag:
Lewy Body Dementia
Synucleinopathies
Alpha-synuclein
Biomarker
Seeding amplification assays
RT-QuIC
Online adgang:https://doi.org/10.1186/s13024-025-00868-3
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