α-Synuclein purification significantly impacts seed amplification assay performance and consistency

Abstract α-Synuclein seed amplification assays are a promising diagnostic tool for synucleinopathies such as Parkinson’s disease and multiple system atrophy. Standardized conditions are required to ensure a high degree of inter- and intra-laboratory reproducibility when performing these assays. A si...

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Principais autores:	Zaid A. M. Al-Azzawi, Nicholas R. G. Silver, Surabhi Mehra, Simeng Niu, Christopher Situ, Wen Luo, Irina Shlaifer, Martin Ingelsson, Bradley T. Hyman, Jean-François Trempe, Thomas M. Durcan, Joel C. Watts, Edward A. Fon
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-11-01
Series:	Acta Neuropathologica Communications
Assuntos:	Neurogenerative diseases Diagnostics Prions RT-QuIC PMCA α-Synuclein
Acceso en liña:	https://doi.org/10.1186/s40478-025-02151-4
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