Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage

Abstract Fusobacterium nucleatum (Fn) is frequently found in colorectal cancers (CRCs). High loads of Fn DNA are detected in CRC tissues with microsatellite instability-high (MSI-H), or with the CpG island hypermethylation phenotype (CIMP). Fn infection is also associated with the inflammatory tumor...

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Autors principals:	Yoshiki Okita, Minoru Koi, Koki Takeda, Ryan Ross, Bhramar Mukherjee, Erika Koeppe, Elena M. Stoffel, Joseph A. Galanko, Amber N. McCoy, Temitope O. Keku, Yoshinaga Okugawa, Takahito Kitajima, Yuji Toiyama, Eric Martens, John M. Carethers
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2020-09-01
Col·lecció:	Gut Pathogens
Matèries:	Fusobacterium nucleatum Colorectal cancer Microsatellite instability CpG island methylator phenotype MSI-L EMAST
Accés en línia:	http://link.springer.com/article/10.1186/s13099-020-00384-3
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