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Electrochemical hydrodefluorination of an aromatic trifluoromethyl group with ammonia as the hydrogen source

The aromatic difluoromethyl group (Ar-CF2H) is an emerging functional group found in pharmaceutical compounds. For synthesis, the hydrodefluorination of Ar-CF3 molecules is a straightforward approach in terms of atom economy and substrate scope. The reported hydrodefluorination reaction focused on t...

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Autori principali: Jie Sheng, Jiaming Cheng, Xu Cheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2024-06-01
Serie:Tetrahedron Chem
Accesso online:http://www.sciencedirect.com/science/article/pii/S2666951X24000135
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