Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression

Abstract Background Neuroinflammation is an important component mechanism in the development of depression. Exosomal transfer of MDD-associated microRNAs (miRNAs) from neurons to microglia might exacerbate neuronal cell inflammatory injury. Results By sequence identification, we found significantly...

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Detalhes bibliográficos

Principais autores:	Xian Xian, Li-Li Cai, Yang Li, Ran-Chao Wang, Yu-Hao Xu, Ya-Jie Chen, Yu-Hang Xie, Xiao-Lan Zhu, Yue-Feng Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-03-01
coleção:	Journal of Nanobiotechnology
Assuntos:	Neuroinflammation Depression Exosomes miR-9-5p Microglial polarization
Acesso em linha:	https://doi.org/10.1186/s12951-022-01332-w
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