Fluvastatin suppresses hemin-induced cell death, reactive oxygen species generation, and elevated labile iron pool

Background: In transfusion-related iron overload, macrophage/reticuloendothelial cells are the first site of haem-derived iron accumulation. The prevention of haem-induced cytotoxicity in macrophages may represent a target for iron overload treatment. Deferasirox, an oral iron chelator, has been use...

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Hlavní autoři:	Shion Imoto, Katsuyasu Saigo, Mari Kono, Ayako Ohbuchi, Tohru Sawamura, Yuji Mizokoshi, Takashi Suzuki
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-12-01
Edice:	Hematology, Transfusion and Cell Therapy
Témata:	Iron overload Macrophage Deferasirox Statins Ferroptosis
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2531137924028323
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