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H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability

Abstract Ubiquitination of the C-terminus of histone H2B (H2BK120ub) is a key histone modification with functions in a wide array of DNA-related processes, best characterized in gene transcription and repair. A role for H2B ubiquitination in DNA replication has been postulated and investigated in ye...

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Principais autores: Filip D Duzanic, Vaishnavi Mohana-Natarajan, Samuele Fisicaro, Collin Bakker, Moses Aouami, Gabriel Amaral, Massimo Lopes, Nitika Taneja, Lorenza Penengo
Formato: Artigo
Idioma:Inglês
Publicado: Springer Nature 2025-10-01
Series:The EMBO Journal
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Acceso en liña:https://doi.org/10.1038/s44318-025-00602-1
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