Absence of Ledgf in mouse brain affects the Kmt2a/b and polycomb balance, synaptic transmission and motor function

Abstract Lens epithelium-derived growth factor (LEDGF), encoded by the Psip1 gene, exists in two splice variants, LEDGF/p75 and LEDGF/p52. Although little is known about its role in the brain, LEDGF has been proposed to play a role in neurogenesis. Since known LEDGF binding partners, such as PogZ, C...

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Hlavní autoři:	Laura Debusschere, Eduard Bentea, Cecilia Iglesias-Herrero, Nicolas Peredo, Siska Van Belle, Nam Joo Van der Veken, Anna Barber-Janer, Dieter Plessers, Wouter Peelaerts, Wout Hannes, Martine Michiels, Chris Van den Haute, Veerle Baekelandt, Zeger Debyser
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-01-01
Edice:	Acta Neuropathologica Communications
On-line přístup:	https://doi.org/10.1186/s40478-025-02216-4
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