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From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes

Abstract Background Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutational signature. Methods We systematically analyzed the smoking-related DNA...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Zhishan Chen, Wanqing Wen, Qiuyin Cai, Jirong Long, Ying Wang, Weiqiang Lin, Xiao-ou Shu, Wei Zheng, Xingyi Guo
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2020-09-01
Schriftenreihe:BMC Cancer
Schlagworte:
Gene expression
Methylation
Tobacco smoking
Mutational signature
Mediation analysis
Online-Zugang:http://link.springer.com/article/10.1186/s12885-020-07368-1
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