ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells

Notch signaling is aberrantly activated in approximately 30% of hepatocellular carcinoma (HCC), significantly contributing to tumorigenesis and disease progression. Expression of the major Notch receptor, NOTCH1, is upregulated in HCC cells and correlates with advanced disease stages, although the m...

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Autors principals:	Tze‐Sian Chan, Li‐Hsin Cheng, Chung‐Chi Hsu, Pei‐Ming Yang, Tai‐Yan Liao, Hsiao‐Yen Hsieh, Pei‐Chun Lin, Wei‐Chun HuangFu, Chih‐Pin Chuu, Kelvin K. Tsai
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2024-03-01
Col·lecció:	Molecular Oncology
Matèries:	ASPM FBXW7 hepatocellular carcinoma Notch signaling NOTCH1 tumorigenesis
Accés en línia:	https://doi.org/10.1002/1878-0261.13589
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