FBXW7 attenuates tumor drug resistance and enhances the efficacy of immunotherapy

FBXW7 (F-box and WD repeat domain containing 7) is a critical subunit of the Skp1-Cullin1-F-box protein (SCF), acting as an E3 ubiquitin ligase by ubiquitinating targeted protein. Through degradation of its substrates, FBXW7 plays a pivotal role in drug resistance in tumor cells and shows the potent...

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Hlavní autoři:	Shimin Chen, Jichun Lin, Jiaojiao Zhao, Qian Lin, Jia Liu, Qiang Wang, Ryan Mui, Leina Ma
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-03-01
Edice:	Frontiers in Oncology
Témata:	FBXW7 drug resistance E3 ligase cancer immunotherapy
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1147239/full
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