Discovery and structural characterization of newly identified mutations in the HBx gene of chronic HBV patients

Abstract HBV infection remains a major cause of chronic liver disease and hepatocellular carcinoma worldwide. HBx is a key regulatory protein involved in viral persistence and host–virus interactions, yet its sequence variability in Middle Eastern populations remains insufficiently characterized. In...

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Hlavní autoři:	Kamyar Mazloum Jalali, Elahe Mosayebnejad Roudbaneh
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-12-01
Edice:	Scientific Reports
Témata:	Hepatitis b virus (HBV) HBx protein Mutational analysis Glycine substitutions Structural modeling Hepatocellular carcinoma (HCC)
On-line přístup:	https://doi.org/10.1038/s41598-025-32368-1
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