HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx

Background & Aims: Although most hepatocellular carcinoma (HCC) cases are driven by hepatitis and cirrhosis, a subset of patients with chronic hepatitis B develop HCC in the absence of advanced liver disease, indicating the oncogenic potential of hepatitis B virus (HBV). We investigated the role...

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Hauptverfasser:	Marc Ringelhan, Svenja Schuehle, Maarten van de Klundert, Elena Kotsiliti, Marie-Laure Plissonnier, Suzanne Faure-Dupuy, Tobias Riedl, Sebastian Lange, Karin Wisskirchen, Frank Thiele, Cho-Chin Cheng, Detian Yuan, Valentina Leone, Ronny Schmidt, Juliana Hünergard, Fabian Geisler, Kristian Unger, Hana Algül, Roland M. Schmid, Roland Rad, Heiner Wedemeyer, Massimo Levrero, Ulrike Protzer, Mathias Heikenwalder
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-10-01
Schriftenreihe:	JHEP Reports
Schlagworte:	Hepatocellular carcinoma HCC Hepatitis B HBV HBx HBV x-protein
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589555924001320
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