The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC

Abstract HIV-1 envelope glycoproteins (Env) from primary HIV-1 isolates typically adopt a pretriggered “closed” conformation that resists to CD4-induced (CD4i) non-neutralizing antibodies (nnAbs) mediating antibody-dependent cellular cytotoxicity (ADCC). CD4-mimetic compounds (CD4mcs) “open-up” Env...

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Главные авторы:	Jonathan Richard, Michael W. Grunst, Ling Niu, Marco A. Díaz-Salinas, Li Zhu, William D. Tolbert, Lorie Marchitto, Fei Zhou, Catherine Bourassa, Hongil Kim, Sri Lakshmi Tejaswi Boodapati, Derek Yang, Ta Jung Chiu, Hung-Ching Chen, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Suneetha Gottumukkala, Wenwei Li, Katrina Dionne, Étienne Bélanger, Debashree Chatterjee, Halima Medjahed, Wayne A. Hendrickson, Joseph Sodroski, Zabrina C. Lang, Abraham J. Morton, Rick K. Huang, Doreen Matthies, Amos B. Smith, Priti Kumar, Walther Mothes, James B. Munro, Marzena Pazgier, Andrés Finzi
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2025-12-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-025-65866-x
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