Low Molar Mass Dextran: One-Step Synthesis With Dextransucrase by Site-Directed Mutagenesis and its Potential of Iron-Loading

Iron dextran is a common anti-anemia drug, and it requires low molar mass dextran as substrate. In this work, we selected 11 amino acid residues in domain A/B of DSR-MΔ2 within a 5-angstrom distance from sucrose for site-directed mutagenesis by molecular docking. Mutation of Q634 did not affect the...

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Bibliografische gegevens

Hoofdauteurs:	Tingting Wang, Zhiming Jiang, Yiya Wang, Hao Wu, Yan Fang, Weiliang Dong, Bin Wu, Jiangfeng Ma, Min Jiang
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Frontiers Media S.A. 2021-09-01
Reeks:	Frontiers in Bioengineering and Biotechnology
Onderwerpen:	GH70 family dextransucrase iron dextran low molar mass dextran site-directed mutagenesis
Online toegang:	https://www.frontiersin.org/articles/10.3389/fbioe.2021.747602/full
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