Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells

Zika virus (ZIKV) infection during pregnancy can result in severe birth defects, such as microcephaly, as well as a range of other related health complications. Heparin, a clinical-grade anticoagulant, is shown to protect neural progenitor cells from death following ZIKV infection. Although heparin...

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Bibliografski detalji

Glavni autori:	Isabel Pagani, Linda Ottoboni, Paola Panina-Bordignon, Gianvito Martino, Guido Poli, Sarah Taylor, Jeremy E. Turnbull, Edwin Yates, Elisa Vicenzi
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2023-09-01
Serija:	Pharmaceuticals
Teme:	Zika virus heparin heparin derivatives heparin precursor fractions protective effects combination therapy
Online pristup:	https://www.mdpi.com/1424-8247/16/10/1385
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