Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells

Zika virus (ZIKV) infection during pregnancy can result in severe birth defects, such as microcephaly, as well as a range of other related health complications. Heparin, a clinical-grade anticoagulant, is shown to protect neural progenitor cells from death following ZIKV infection. Although heparin...

Descrición completa

Detalles Bibliográficos

Principais autores:	Isabel Pagani, Linda Ottoboni, Paola Panina-Bordignon, Gianvito Martino, Guido Poli, Sarah Taylor, Jeremy E. Turnbull, Edwin Yates, Elisa Vicenzi
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2023-09-01
Series:	Pharmaceuticals
Assuntos:	Zika virus heparin heparin derivatives heparin precursor fractions protective effects combination therapy
Acceso en liña:	https://www.mdpi.com/1424-8247/16/10/1385
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!