Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy

BackgroundThe ongoing treatment modalities for breast cancer (BC) primarily rely on the expression status of ER, PR and HER-2 receptors in BC tissues. Our strategy of chemosensitization provides new insights to counter chemoresistance, a major obstacle that limits the benefits of chemotherapy of mam...

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Autores principales:	Nair Hariprasad Haritha, Akbar Nawab, Vinod Vijayakurup, Nikhil Ponnoor Anto, Vijayasteltar B. Liju, Vijai V. Alex, Areekkara Nisthul Amrutha, Sreekumar U. Aiswarya, Mundanattu Swetha, Balachandran S. Vinod, Sankar Sundaram, Maria V. Guijarro, Thomas Herlevich, Archana Krishna, Nesteena K. Nestory, Smitha V. Bava, Chittalakkottu Sadasivan, Maria Zajac-Kaye, Ruby John Anto
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2021-07-01
Colección:	Frontiers in Oncology
Materias:	breast cancer thymidylate synthase chemoresistance chemosensitization curcumin 5-FU
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fonc.2021.656804/full
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