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The mTOR Inhibitor Rapamycin Prevents General Anesthesia-Induced Changes in Synaptic Transmission and Mitochondrial Respiration in Late Postnatal Mice

Preclinical animal studies have continuously reported the possibility of long-lasting neurotoxic effects after general anesthesia in young animals. Such studies also show that the neurological changes induced by anesthesia in young animals differ by their neurodevelopmental stage. Exposure to anesth...

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Principais autores: Xianshu Ju, Min Jeong Ryu, Jianchen Cui, Yulim Lee, Sangil Park, Boohwi Hong, Sungho Yoo, Won Hyung Lee, Yong Sup Shin, Seok-Hwa Yoon, Gi Ryang Kweon, Yoon Hee Kim, Youngkwon Ko, Jun Young Heo, Woosuk Chung
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-01-01
coleção:Frontiers in Cellular Neuroscience
Assuntos:
general anesthesia
mTOR
neurodevelopment
neurotoxicity
synaptic transmission
Acesso em linha:https://www.frontiersin.org/article/10.3389/fncel.2020.00004/full
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