Mitochondrial dysfunction precedes hippocampal IL-1β transcription and cognitive impairments after low-dose lipopolysaccharide injection in aged mice

Acute cognitive impairments termed delirium often occur after inflammatory insults in elderly patients. While previous preclinical studies suggest mitochondria as a target for reducing neuroinflammation and cognitive impairments after LPS injection, fewer studies have evaluated the effects of a low-...

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Autors principals:	Yulim Lee, Xianshu Ju, Jianchen Cui, Tao Zhang, Boohwi Hong, Yoon Hee Kim, Youngkwon Ko, Jiho Park, Chul Hee Choi, Jun Young Heo, Woosuk Chung
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-04-01
Col·lecció:	Heliyon
Matèries:	Cognition Inflammation Lipopolysaccharide Mitochondria Neuroinflammation Old age
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2405844024050059
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