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Adenosine A<sub>2A</sub> Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ<sub>1–42</sub> to Model Early Alzheimer’s Disease

The intracerebroventricular (icv) injection of amyloid peptides (Aβ) models Alzheimer’s disease (AD) in mice, as typified by the onset within 15 days of deficits of memory and of hippocampal long-term potentiation (LTP) that are prevented by the blockade of adenosine A<sub>2A</sub> receptors (A<sub>...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Cátia R. Lopes, António C. Silva, Henrique B. Silva, Paula M. Canas, Paula Agostinho, Rodrigo A. Cunha, João Pedro Lopes
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2023-07-01
Schriftenreihe:Biomolecules
Schlagworte:
adenosine
A<sub>2A</sub> receptor
Alzheimer’s disease
memory
LTP
synapse
Online-Zugang:https://www.mdpi.com/2218-273X/13/8/1173
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