Neurophysiological In Vitro Model of Amyloid-β-Induced Deficits of Hippocampal LTP Involving Neuronal Adenosine A_2A Receptor Dysfunction Through CD73

Amyloid-β peptides (Aβ) are considered a main culprit of Alzheimer’s disease (AD), leading to synaptic dysfunction and memory deficits. Although studies in animal models of AD converge to show alterations of synaptic plasticity, namely of long-term potentiation (LTP), the mechanisms through which Aβ...

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Bibliographic Details

Main Authors:	Francisco Q. Gonçalves, Henrique B. Silva, Ângelo R. Tomé, Paula Agostinho, Rodrigo A. Cunha, João P. Lopes
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2026-03-01
Series:	Cells
Subjects:	Aβ hippocampus neurophysiological model LTP adenosine A<sub>2A</sub> receptor
Online Access:	https://www.mdpi.com/2073-4409/15/6/510
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