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Modification of γ‐secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease

Abstract Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid plaque formation in the brain of these patients. Little is known however whether ageing, the major risk factor for sporadic AD, affe...

Täydet tiedot

Tallennettuna:
Päätekijät: Francesc X. Guix, Tina Wahle, Kristel Vennekens, An Snellinx, Lucía Chávez‐Gutiérrez, Gerard Ill‐Raga, Eva Ramos‐Fernandez, Cristina Guardia‐Laguarta, Alberto Lleó, Muriel Arimon, Oksana Berezovska, Francisco J. Muñoz, Carlos G. Dotti, Bart De Strooper
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer Nature 2012-05-01
Sarja:EMBO Molecular Medicine
Aiheet:
ageing
Alzheimer's disease
gamma‐secretase
peroxynitrite
presenilin‐1
Linkit:https://doi.org/10.1002/emmm.201200243
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