Identification of a key role of widespread epigenetic drift in Barrett’s esophagus and esophageal adenocarcinoma

Abstract Background Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift. However, the evolving patterns, functional consequences, and dynamics of epigenetic drift during carcinogenesis remain largely...

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Detalhes bibliográficos

Principais autores:	E. Georg Luebeck, Kit Curtius, William D. Hazelton, Sean Maden, Ming Yu, Prashanthi N. Thota, Deepa T. Patil, Amitabh Chak, Joseph E. Willis, William M. Grady
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-10-01
coleção:	Clinical Epigenetics
Assuntos:	Barrett’s esophagus (BE) Esophageal adenocarcinoma (EAC) Tissue age Epigenetic drift DNA methylation Neoplastic progression
Acesso em linha:	http://link.springer.com/article/10.1186/s13148-017-0409-4
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