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Modeling Fragile X Syndrome: Characterizing Fmr1 Gene Knockout Mice across Genotype, Behavior, and Morphology

Objective: Fragile X syndrome (FXS) is a hereditary condition resulting from dynamic mutations in the Fmr1 gene, leading to reduced or absent fragile X mental retardation protein (FMRP). Although molecular genetic diagnostics for FXS have advanced, there is currently a lack of effective clinical tre...

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Автори: Yonghua Liao, Junjie Liu, Jinyuan Zhang, Da Chen, Yifan Liu, Zhuolin Li, Hao Su, Jiaye Tang, Shengqiang Chen
Формат: Artigo
Мова:Inglês
Опубліковано: Wolters Kluwer Medknow Publications 2024-09-01
Серія:Neurological Sciences and Neurophysiology
Предмети:
behavioral studies
fmr1
fragile x mental retardation protein
fragile x syndrome
genotype
morphology
Онлайн доступ:https://journals.lww.com/10.4103/nsn.nsn_25_24
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