Azelaic acid attenuates CCL2/CCR2 axis-mediated skin trafficking of acute myeloid leukemia cells through NF-κB/MAPK signaling modulation in keratinocytes

Abstract Background The involvement of CCL2/CCR2 in leukemic cell infiltration into the skin, specifically in leukemia cutis (LC), remains largely unexplored. Oxidative stress has been demonstrated to induce the upregulation of CCL2 expression, while the antioxidant properties of azelaic acid (AZA)...

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Principais autores:	Si Jiang, Linlu Ma, Tingting Huang, Tianran Wang, Fuling Zhou, Xiaoyan Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-07-01
coleção:	BMC Cancer
Assuntos:	Acute myeloid leukemia Leukemia cutis mice model CCL2/CCR2 Azelaic acid Migration
Acesso em linha:	https://doi.org/10.1186/s12885-025-14648-1
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