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Inhibition of CCR2 attenuates neuroinflammation and neuronal apoptosis after subarachnoid hemorrhage through the PI3K/Akt pathway

Abstract Background Neuroinflammation and neuronal apoptosis are closely associated with a poor prognosis in patients with subarachnoid hemorrhage (SAH). We investigated the role of C–C motif chemokine receptor 2 (CCR2) in SAH. Methods Pre-processed RNA-seq transcriptome datasets GSE167110 and GSE79...

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Autors principals: Qi Tian, Yujia Guo, Shi Feng, Chengli Liu, Peibang He, Jianfeng Wang, Wenrui Han, Chen Yang, Zhan Zhang, Mingchang Li
Format: Artigo
Idioma:Inglês
Publicat: BMC 2022-12-01
Col·lecció:Journal of Neuroinflammation
Matèries:
Apoptosis
CCR2
Inflammation
Neuron
Subarachnoid hemorrhage
Accés en línia:https://doi.org/10.1186/s12974-022-02676-8
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